Journal of the Chemical Society. Perkin transactions II p. 825 - 828 (1980)
Update date:2022-08-03
Topics:
Senogles, Ernest
Thomas, Roderick A.
The kinetics and mechanism of the acid-catalysed hydrolysis of N-vinylpyrrolidin-2-one (1) has been studied using n.m.r. spectroscopy and spectrophotometry.At temperatures near 0 deg C N-(1-hydroxyethyl)pyrrolidine-2-one (3) is the main product.At higher temperatures this decomposes into acetaldehyde and pyrrolidin-2-one (4) and the latter reacts with an excess of N-vinylpyrrolidine-2-one to give 1,1-bis-(N-2-oxopyrrolidinyl)ethane (5).The rate determining step of the hydrolysis reaction has been established as proton transfer to N-vinylpyrrolidin-2-one and the reaction conforms to a general acid catalysis mechanism.A Broensted exponent value of 0.68 +/- 0.03 was obtained with a series of carboxylic acids.
View Morewebsite:http://www.debyesci.com
Contact:+85221376140
Address:Rm. 19C, Lockhart Ctr., 301-307 Lockhart Rd., Wan Chai
Shanghai Yingrui Biopharma Co., Ltd
Contact:021-3358 8661*8003
Address:shanghai
Taizhou Huading Chemical Co.,Ltd(expird)
Contact:+86-576-88583898
Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Contact:86 21 3772 9386
Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China
Contact:+91 - 22 - 26355700
Address:17, Lotus Business Park, Andheri West
Doi:10.1016/S0040-4020(99)00680-8
(1999)Doi:10.1021/ja953976y
(1996)Doi:10.1246/bcsj.69.289
(1996)Doi:10.1021/jo951526i
(1996)Doi:10.1016/0968-0896(96)00082-X
(1996)Doi:10.1002/anie.200462101
(2005)
