Acylation of diethyl (ethoxycarbonyl)fluoromethylphosphonate using magnesium chloride-triethylamine: A facile synthesis of α-fluoro β-keto esters

DOI: 10.1016/0040-4039(95)02224-4

Source and publish data:

Tetrahedron Letters p. 653 - 654 (1996)

Update date:2022-08-03

Topics:

Authors:

Kim Kim

Rhie Rhie

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)02224-4

A facile synthesis of α-fluoro β-keto esters, via diacylation reaction of diethyl (ethoxycarbonyl)fluoromethylphosphonate with aromatic carboxylic acid chlorides in the presence of magnesium chloride-triethylamine followed by deacylation, is described.

Full text of DOI:10.1016/0040-4039(95)02224-4

Products guided by the article

Product name:ethyl 2-fluoro-3-oxo-3-(m-bromophenyl)propionate

Cas No:174714-42-2

R&D Labs maybe for 174714-42-2

TIANJIN ZHONGXIN CHEMTECH CO.,LTD.

Contact:86-022-89880739

Address:10B, Pan China International Center, No. 931 YingKou Road, TangGu, Tianjin, China, 300451
Antimex Chemical Limied

website:http://www.antimex.com

Contact:0086-21-50563169

Address:Room1027,No.Jinyu Road,Pudong
Kaiping Genuine Biochemical Pharmaceutical Co.,Ltd.

Contact:+86-750-2881198

Address:No.1, Xinke Road, Shatang Town, Kaiping, Guangdong Province, P.R.China
Chengdu D-Innovation Pharmaceutical Co., Ltd

Contact:86-28-85105536

Address:1001, B6, No.88 Keyuan South Road, Chengdu Hi-Tech Zone
Huayi Isotopes Co.

Contact:+ 86 512 52491118

Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China

Relevant to this article

Enantioselective synthesis of the four isomers of the biologically active metabolite of the 2-arylpropanoic acid NSAID, ximoprofen, and assessment of their inhibitory activity on human platelet cyclo-oxygenase in vitro

Doi:10.1016/0957-4166(95)00443-2
(1996)
Liquid-Liquid Extraction Protocol for the Removal of Aldehydes and Highly Reactive Ketones from Mixtures

Doi:10.1021/acs.oprd.7b00231
(2017)
Synthesis of symmetrical and unsymmetrical ureas using unsymmetrical diaryl carbonates

Doi:10.1080/00397919608003622
(1996)
The preparation and pharmacological properties of psi-corbasil.

Doi:10.1111/j.2042-7158.1969.tb08375.x
(1969)
Selective 1,4-addition of arenes to 3-chloro-3-cyclobutene-1,2-dione under friedel-crafts conditions. Synthesis and reactivity of 4-aryl-3-chloro-2- hydroxy-2-cyclobuten-1-ones

Doi:10.1021/jo952062r
(1996)
The synthesis and fluorescence behaviour of phthalocyanines unsymmetrically substituted with naphthol and carboxy groups

Doi:10.1016/j.dyepig.2009.11.010
(2010)

Article Doi