Acylation of diethyl (ethoxycarbonyl)fluoromethylphosphonate using magnesium chloride-triethylamine: A facile synthesis of α-fluoro β-keto esters

DOI: 10.1016/0040-4039(95)02224-4

Source and publish data:

Tetrahedron Letters p. 653 - 654 (1996)

Update date:2022-08-03

Topics:

Authors:

Kim Kim

Rhie Rhie

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(95)02224-4

A facile synthesis of α-fluoro β-keto esters, via diacylation reaction of diethyl (ethoxycarbonyl)fluoromethylphosphonate with aromatic carboxylic acid chlorides in the presence of magnesium chloride-triethylamine followed by deacylation, is described.

Full text of DOI:10.1016/0040-4039(95)02224-4

Products guided by the article

Product name:ethyl 2-fluoro-3-oxo-3-(m-bromophenyl)propionate

Cas No:174714-42-2

R&D Labs maybe for 174714-42-2

SJZ THLD IMP & EXP CO LTD

website:http://www.truewingroup.com

Contact:86-311-66699812

Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
ABA Chemicals (Shanghai) Limited

Contact:021- 5115 9199-232

Address:Suite 18D, #201 Ningxia Road,
Synchem Pharma Co.,Ltd(expird)

Contact:+0086-21-61984905-1

Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong，Yuandong Road Fengxian District, Shanghai ,China
MS( MAOSHENG )Chemical CO.,LTD

Contact:+86-519-82726678.82726378

Address:TAOXI INDUSTRY ZONE JINTAN
Xiamen Hisunny Chemical Co.,Ltd

website:http://www.hisunnychem.com

Contact:+86-592-3327115

Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China

Relevant to this article

Enantioselective synthesis of the four isomers of the biologically active metabolite of the 2-arylpropanoic acid NSAID, ximoprofen, and assessment of their inhibitory activity on human platelet cyclo-oxygenase in vitro

Doi:10.1016/0957-4166(95)00443-2
(1996)
Liquid-Liquid Extraction Protocol for the Removal of Aldehydes and Highly Reactive Ketones from Mixtures

Doi:10.1021/acs.oprd.7b00231
(2017)
Synthesis of symmetrical and unsymmetrical ureas using unsymmetrical diaryl carbonates

Doi:10.1080/00397919608003622
(1996)
The preparation and pharmacological properties of psi-corbasil.

Doi:10.1111/j.2042-7158.1969.tb08375.x
(1969)
Selective 1,4-addition of arenes to 3-chloro-3-cyclobutene-1,2-dione under friedel-crafts conditions. Synthesis and reactivity of 4-aryl-3-chloro-2- hydroxy-2-cyclobuten-1-ones

Doi:10.1021/jo952062r
(1996)
The synthesis and fluorescence behaviour of phthalocyanines unsymmetrically substituted with naphthol and carboxy groups

Doi:10.1016/j.dyepig.2009.11.010
(2010)

Article Doi