Tetrahedron p. 1493 - 1502 (1996)
Update date:2022-07-30
Topics:
Klosel
Konig
Lehnhoff
Karl
The 1,1-dianisyl-2,2,2-trichloroethyl group (DATE, 1) was introduced as a new 2'-hydroxyl protecting group of ribonucleotides. The usefulness of DATE as a 2'-OH protection was demonstrated in the solid phase synthesis of a dinucleotide by the phosphoramidite method. Starting from 2'-O-DATE-uridine (5), a suitable protected building block 7 was thus prepared and condensed in a conventional DNA synthesizer with the unprotected 5'-hydroxyl group of thymidine bound to a support via the 3'-hydroxy group. The resulting chimeric dinucleotide was cleaved from the support and the protecting groups were removed to yield 8. Cleavage of DATE was performed by means of lithium cobalt(I)phthalocyanine smoothly and quantitatively without any by-product formation.
View MoreContact:+86-519-86339586,13584329896
Address:Changzhou Scientific and Education Park
Contact:86-27-84888681
Address:Wuhan economic & technology development zone
Shanghai Yurui Biotechnology(Anyang) Pharmaceutical Co., Ltd
Contact:+86-0372-3662335 +86-0372-3661988
Address:hanling industrial park anyang
Contact:0086 533 2282832
Address:Zibo,Shandong
Contact:86-21-34622192,13917187091,21-34622765
Address:No. 500 Caobao Road Shanghai P.R China
Doi:10.1021/acs.orglett.5b00996
(2015)Doi:10.1002/cctc.201900221
(2019)Doi:10.1016/S0040-4020(01)88591-4
(1983)Doi:10.1016/0960-894X(95)00579-I
(1996)Doi:10.1002/anie.201711753
(2018)Doi:10.1002/ejoc.200500937
(2006)