Tetrahedron p. 1493 - 1502 (1996)
Update date:2022-07-30
Topics:
Klosel
Konig
Lehnhoff
Karl
The 1,1-dianisyl-2,2,2-trichloroethyl group (DATE, 1) was introduced as a new 2'-hydroxyl protecting group of ribonucleotides. The usefulness of DATE as a 2'-OH protection was demonstrated in the solid phase synthesis of a dinucleotide by the phosphoramidite method. Starting from 2'-O-DATE-uridine (5), a suitable protected building block 7 was thus prepared and condensed in a conventional DNA synthesizer with the unprotected 5'-hydroxyl group of thymidine bound to a support via the 3'-hydroxy group. The resulting chimeric dinucleotide was cleaved from the support and the protecting groups were removed to yield 8. Cleavage of DATE was performed by means of lithium cobalt(I)phthalocyanine smoothly and quantitatively without any by-product formation.
View MoreContact:+86-710-3516804
Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Shanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
QINGDAO ON-BILLION INDUSTRAIL CO.,LTD
website:http://www.obn.com.cn
Contact:+86-15005320811 +86-532-80681989
Address:F35 Parkson Mansion No.44-60 Zhongshan Rd.
Xian Changyue Biological Technology Co., Ltd.
website:https://www.xachangyue.com/
Contact:+86-029-62886900
Address:Keji Road NO.70
Doi:10.1021/acs.orglett.5b00996
(2015)Doi:10.1002/cctc.201900221
(2019)Doi:10.1016/S0040-4020(01)88591-4
(1983)Doi:10.1016/0960-894X(95)00579-I
(1996)Doi:10.1002/anie.201711753
(2018)Doi:10.1002/ejoc.200500937
(2006)