
Journal of the Chemical Society. Perkin transactions I p. 255 - 258 (1996)
Update date:2022-08-03
Topics:
Theil, Fritz
Ballschuh, Sibylle
Von Janta-Lipinski, Martin
Johnson, Roger A.
The carbocyclic nucleoside analogues 8 and ent-8 have been prepared based on the enantiomerically pure bicyclo[3.1.0]hexane monoacetates 5 and ent-5 which were obtained by a lipase-catalysed asymmetrization of the meso-bicyclo[3.1.0]hexane derivatives 4 and 6, respectively. By an enantiodivergent approach both nucleoside analogues 8 and ent-8 have been synthesized starting from the common enantiomer 5. Furthermore, the adenine derivative ent-8 has been obtained from the monoacetate ent-5.
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