Synthesis of enantiopure 1,2-didehydropyrrolidine, D-proline, and oxazoline derivatives via Staudinger-aza-Wittig cyclization of γ-azido aldehydes

DOI: 10.1055/s-1996-4162

Source and publish data:

Synthesis p. 123 - 132 (1996)

Update date:2022-08-04

Topics:

Authors:

Mulzer, Johann

Meier, Andreas

Buschmann, Juergen

Luger, Peter

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Article abstract of DOI:10.1055/s-1996-4162

The synthesis of 3-, 3,5- and 3,4,5-substituted prolines 1 and oxazolines 3 from inexpensive D-mannitol, employing the Staudinger-aza-Wittig cyclization as a key step, is described.

Full text of DOI:10.1055/s-1996-4162

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