Generation of 6-alkylidene/benzylidene-3,6-dihydropyrazin-2(1H)-ones by reaction of 6-bromomethylpyrazin-2(1H)-ones with methoxide and further conversion into specific piperazine-2,5-diones and pyrazin-2(1H)-ones

Article abstract of DOI:10.1039/p19960000231

3-Aryl-, 3-benzyl- and 3-methoxy-6-(1-bromoalkyl/benzyl)-5-chloropyrazin-2(1H)-ones 6 have been synthesised and converted into new 6-alkylidene/benzylidene-5-chloro-3,6-dihydropyrazin-2(1H)-ones 7 by reaction with methoxide in THF. With 2 equiv. of alkoxi