Synthesis and biological activity of conformationally constrained sialyl Lewis X analogues with reduced carbohydrate character

DOI: 10.1016/0960-894X(96)00008-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 239 - 244 (1996)

Update date:2022-08-03

Topics:

Authors:

Bamford Bamford

Bird Bird

Gore Gore

Holmes Holmes

Priest Priest

Prodger Prodger

Saez Saez

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00008-X

Two conformationnaly constrained analogues of sialyl Lewis X have been synthesised in which the GlcNAc residue has been replaced with cyclohexyl and phenyl rings. The cyclohexyl derived compound was equipotent to sLex and sLea in vitro, suggesting the main role of the GlcNAc residue in sLex is conformational, and represents a simplified inhibitor of adhesion.

Full text of DOI:10.1016/0960-894X(96)00008-X

Products guided by the article

Product name:2-((2S,3S,4R,5R,6S)-3,4,5-Tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-phenol

Cas No:175473-01-5

R&D Labs maybe for 175473-01-5

shijiazhuang alkay chemicals co..ltd(expird)

Contact:86-311-67692035

Address:2601,juntang building,qiaodong district,shijiazhuang
Hubei ShiNan Pharmaceutical Chemical co., Ltd.(expird)

Contact:+86-13554447107

Address:Wuhan HongShanOu wu no road 378 future residence building 1 unit 14 layer no. 1401 A
Jiangsu Fengshan Group Co., Ltd.

Contact:86-25-86558671

Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
SHANGHAI ARCADIA BIOTECHNOLOGY LTD.

Contact:+86-21-61353236

Address:SUITE 901, BUILDING WENSLI, 1378 LU JIA BANG RD, SHANGAHI 200011, P.R.CHINA
Suzhou Chiral Pharmaceuticals Co., Ltd.

Contact:86-0512-63197058

Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park

Relevant to this article

Synthesis and biological activity of novel tricyclic β-lactams

Doi:10.1016/0960-894X(96)00061-3
(1996)
Inhibitors of leukotriene B₄. Synthesis and SAR of new β-enaminoester open-chain analogues of Zeneca ZD2138

Doi:10.1016/0960-894X(96)00058-3
(1996)
Doi:10.1021/ja01218a505
(1945)
Comparative studies of palladium and copper-catalysed γ-arylation of silyloxy furans with diaryliodonium salts

Doi:10.1016/j.tet.2019.02.042
(2019)
Four step synthesis of a 5′-deoxy-5′-iodomethylthymidine

Doi:10.1016/0040-4039(96)00090-1
(1996)
Synthesis of a new carbohydrate mimetics: 'Carbopeptoid' containing a C-1 carboxylate and C-2 amino group

Doi:10.1016/0040-4039(96)00094-9
(1996)

Article Doi