Four step synthesis of a 5′-deoxy-5′-iodomethylthymidine

Article abstract of DOI:10.1016/0040-4039(96)00090-1

The conversion of an alkylsulfonate to an iodide with triphenylphosphine/iodine in benzene has been performed for a nucleoside. Starting from thymidine, 3′-protected 5′-deoxy-5′-iodomethylthymidine was synthesized in 4 steps.