Synthesis and biological activity of novel tricyclic β-lactams

Article abstract of DOI:10.1016/0960-894X(96)00061-3

The synthesis of the preliminary data on microbiological activity of some tricyclic β-lactam derivatives (4), analogues of synthetic 'trinems', is described. Compound 14, key intermediate in the synthesis of 18, was stereoselectively obtained from its unsubstituted analogue, 12B, in 4 steps through enolphosphate 13.