Synthesis of 7-membered cyclic oxamides: Novel HIV-1 protease inhibitors

Article abstract of DOI:10.1016/0040-4039(96)00013-5

An intermediate with three chiral centers, constructed by two key reactions viz. asymmetric allylboration and Sharpless epoxidation, has been used for the synthesis of novel 7-membered cyclic oxamides.