Iron(III) picolinate-catalyzed oxidative demethylation of N,N- dimethylaniline with hydrogen peroxide in the presence of acetic anhydride

DOI: 10.1248/cpb.45.2089

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2089 - 2092 (1997)

Update date:2022-08-03

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Authors:

Kotani, Eiichi

Takeya, Tetsuya

Shimizu, Hideaki

Egawa, Hirotaka

Yamamoto, Takeshi

Tobinaga, Seisho

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Article abstract of DOI:10.1248/cpb.45.2089

Oxidation of N,N-dimethylaniline (1) utilizing the Fe(PA)₃/H₂O₂/MeCN system and the Fe(ClO₄)₃-9H₂O/PAH-Py/H₂O₂/MeCN system, simple model systems for mono-oxygenases, in the presence of acetic arthydride (Ac₂O) afforded predominantly the N-acetylative demethylation product, N- methylacetanilide (4), along with a few other compounds.

Full text of DOI:10.1248/cpb.45.2089

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