Bioorganic and Medicinal Chemistry Letters p. 815 - 818 (1996)
Update date:2022-08-03
Topics:
Switzer, Christopher
Prakash, Thazha P.
Ahn, Yoonmo
A novel bifurcated nucleoside that bears an adenine group trimethylene linked to the 5-position of uracil, 5-(omega-adenylpropyl)-2'-deoxyuridine, has been synthesized and incorporated into a DNA dodecamer. This nucleoside is designed to both intercalate and hydrogen bond when incorporated into an oligonucleotide helix. Initial results of its influence on helix properties are reported.
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