Easy and general access to α,α-difluoromethylene phosphonothioic acids. A new class of compounds

Article abstract of DOI:10.1016/0040-4039(96)00238-9

The preparation of dibenzyl α,α-difluoromethylphosphonothioate 10 from the reaction between the corresponding phosphonate 9 and Lawesson's reagent is reported. Treatment of 10 with lithium diisopropylamide and a variety of electrophiles demonstrate the possibility of functionalizing it. Reductive debenzylation of the adducts affords the sodium salts of α,α-difluoromethylenephosphonothioates 22 which upon acidic treatment deliver the corresponding acids 4.