Tetrahedron Letters p. 2229 - 2232 (1996)
Update date:2022-07-29
Topics:
Piettre, Serge R.
Raboisson, Pierre
The preparation of dibenzyl α,α-difluoromethylphosphonothioate 10 from the reaction between the corresponding phosphonate 9 and Lawesson's reagent is reported. Treatment of 10 with lithium diisopropylamide and a variety of electrophiles demonstrate the possibility of functionalizing it. Reductive debenzylation of the adducts affords the sodium salts of α,α-difluoromethylenephosphonothioates 22 which upon acidic treatment deliver the corresponding acids 4.
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