Synthesis of the interferon-α inducer imiquimod by thermal electrocyclic reactions of 1- and 2-azahexatriene systems

DOI: 10.1248/cpb.44.709

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 709 - 714 (1996)

Update date:2022-08-05

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Authors:

Yoshioka, Haruyuki

Matsuya, Yuhji

Choshi, Tominari

Sugino, Eiichi

Hibino, Satoshi

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Article abstract of DOI:10.1248/cpb.44.709

The interferon-α inducer imiquimod (1), possessing an imidazo[4,5- c]quinoline ring, has been newly synthesized by two routes on thermal electrocyclic reactions of 1- and 2-azahexatriene systems involving the imidazole 4,5-bond.

Full text of DOI:10.1248/cpb.44.709

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