A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates

DOI: 10.1016/0960-894X(96)00104-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 763 - 766 (1996)

Update date:2022-08-03

Topics:

Authors:

Annoura, Hirokazu

Fukunaga, Atsuko

Uesugi, Mayumi

Tatsuoka, Toshio

Horikawa, Yoshiko

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Article abstract of DOI:10.1016/0960-894X(96)00104-7

7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates (4a-c), highly potent antagonists for a phospholipase C-linked metabotropic glutamate receptor, mGluR1, were synthesized through cyclopropanation onto 4-oxo-4H-1-benzopyran-2-carboxylates (5a-c) utilizing dimethyloxosulfonium methylid followed by treatment with hydroxylamine.

Full text of DOI:10.1016/0960-894X(96)00104-7

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