A new model for the stereoselective construction of the Kdo structure through a mechanism similar to that suggested for the enzyme Kdo8P synthase

Article abstract of DOI:10.1016/0040-4039(96)00608-9

Stereospecific chemical synthesis of the Kdo structure was demonstrated using a mechanism similar to that suggested for the enzyme Kdo8P synthase. The derivative of D-(-)-arabinose (compound 3), in which the enolpyruvate moiety is attached at C-3 hydroxyl, was synthesized in 12 chemical steps and an intramolecular condensation of enolpyruvate and aldehyde functions was examined, under Lewis acid conditions.