Asymmetric synthesis of (S)-(+)- and (R)-(-)-NZ-105 through the modified Michaelis-Arbuzov rearrangement as a key step

DOI: 10.1248/cpb.44.1132

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1132 - 1134 (1996)

Update date:2022-07-31

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Authors:

Kato, Tatsuhisa

Tejima, Mamiko

Ebiike, Hirosato

Achiwa, Kazuo

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Article abstract of DOI:10.1248/cpb.44.1132

The asymmetric synthesis of the (S)-(+)- and (R)-(-)-NZ-105 from the prochiral compound (1) was realized by using the modified Hunsdiecker reaction followed by the modified Michaelis-Arbuzov reaction with zerovalent palladium.

Full text of DOI:10.1248/cpb.44.1132

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