Bioorganic and Medicinal Chemistry Letters p. 1341 - 1344 (2003)
Update date:2022-08-03
Topics:
Youngman, Mark A.
Carson, John R.
Lee, Jung S.
Dax, Scott L.
Zhang, Sui-Po
Colburn, Ray W.
Stone, Dennis J.
Codd, Ellen E.
Jetter, Michele C.
The synthesis and structure-activity relationships of a novel series of aroylpyrrole alkylamides as potent selective bradykinin B2 receptor antagonists are described. Several members of this series display nanomolar affinity at the B2 receptor and show activity in an animal model of antinociception.
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