Bioorganic and Medicinal Chemistry Letters p. 1745 - 1750 (1998)
Update date:2022-07-29
Topics:
Batt, Douglas G.
Petraitis, Joseph J.
Sherk, Susan R.
Copeland, Robert A.
Dowling, Randine L.
Taylor, Tracy L.
Jones, Elizabeth A.
Magolda, Ronald L.
Jaffee, Bruce D.
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
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Doi:10.1021/ja01132a530
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(1998)
