Bioorganic and Medicinal Chemistry Letters p. 1371 - 1374 (1996)
Update date:2022-08-03
Topics:
Han, Qi
Lafontaine, Jennifer
Bacheler, Lee T.
Rayner, Marlene M.
Klabe, Ronald M.
Erickson-Viitanen, Susan
Lam, Patrick Y.S.
Several bis-N-alkylated (+)-biotin derivatives were synthesized and evaluated for activities against HIV-1 protease. The most potent inhibitor, 2D, synthesized in two steps from (+)-biotin, has K(i) of 0.50 μM and antiviral IC90 of 7 μM. The (+
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(1966)
