Synthesis of (+)-biotin derivatives as HIV-1 protease inhibitors

DOI: 10.1016/0960-894X(96)00233-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1371 - 1374 (1996)

Update date:2022-08-03

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Authors:

Han, Qi Han, Qi

Lafontaine, Jennifer

Bacheler, Lee T.

Rayner, Marlene M.

Klabe, Ronald M.

Erickson-Viitanen, Susan

Lam, Patrick Y.S.

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Article abstract of DOI:10.1016/0960-894X(96)00233-8

Several bis-N-alkylated (+)-biotin derivatives were synthesized and evaluated for activities against HIV-1 protease. The most potent inhibitor, 2D, synthesized in two steps from (+)-biotin, has K(i) of 0.50 μM and antiviral IC₉₀ of 7 μM. The (+

Full text of DOI:10.1016/0960-894X(96)00233-8

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