Bioorganic and Medicinal Chemistry Letters p. 2263 - 2268 (1996)
Update date:2022-08-02
Topics:
Gallant, Michel
Dufresne, Claude
Gareau, Yves
Guay, Daniel
Leblanc, Yves
Prasit, Petpiboon
Rochette, Chantal
Sawyer, Nicole
Slipetz, Deborah M.
Tremblay, Nathalie
Metters, Kathleen M.
Labelle, Marc
A new class of potent ligand for the human peripheral cannabinoid (hCB2) receptor is described. Two indole analogs 13 and 17 exhibited nanomolar potencies (K(i)) with good selectivity for the hCB2 receptor over the human central cannabinoid (hCB1) receptor.
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