New class of potent ligands for the human peripheral cannabinoid receptor

DOI: 10.1016/0960-894X(96)00426-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2263 - 2268 (1996)

Update date:2022-08-02

Topics:

Authors:

Gallant, Michel

Dufresne, Claude

Gareau, Yves

Guay, Daniel

Leblanc, Yves

Prasit, Petpiboon

Rochette, Chantal

Sawyer, Nicole

Slipetz, Deborah M.

Tremblay, Nathalie

Metters, Kathleen M.

Labelle, Marc

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Article abstract of DOI:10.1016/0960-894X(96)00426-X

A new class of potent ligand for the human peripheral cannabinoid (hCB₂) receptor is described. Two indole analogs 13 and 17 exhibited nanomolar potencies (K(i)) with good selectivity for the hCB₂ receptor over the human central cannabinoid (hCB₁) receptor.

Full text of DOI:10.1016/0960-894X(96)00426-X

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