Bioorganic and Medicinal Chemistry Letters p. 913 - 918 (1999)
Update date:2022-08-03
Topics:
Bachand, Benoit
DiMaio, John
Siddiqui, M. Arshad
A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity α to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.
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