Asymmetric synthesis. XLI. Totally stereoselective synthesis of 1,3- disubstituted tetrahydroisoquinolines via the CN(R,S) method

DOI: 10.1016/0040-4039(96)00819-2

Source and publish data:

Tetrahedron Letters p. 4369 - 4372 (1996)

Update date:2022-08-03

Topics:

Authors:

Gosmann Gosmann

Guillaume

Husson Husson

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Article abstract of DOI:10.1016/0040-4039(96)00819-2

Optically active cis- or trans-1,3-disubstituted tetrahydroisoquinolines can be prepared selectively from the same oxazolidine 4. This latter is easily obtained from keto-acid 1 and (R)-(-)-phenylglycinol.

Full text of DOI:10.1016/0040-4039(96)00819-2

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Product name:(S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

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