Asymmetric synthesis. XLI. Totally stereoselective synthesis of 1,3- disubstituted tetrahydroisoquinolines via the CN(R,S) method

DOI: 10.1016/0040-4039(96)00819-2

Source and publish data:

Tetrahedron Letters p. 4369 - 4372 (1996)

Update date:2022-08-03

Topics:

Authors:

Gosmann Gosmann

Guillaume

Husson Husson

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)00819-2

Optically active cis- or trans-1,3-disubstituted tetrahydroisoquinolines can be prepared selectively from the same oxazolidine 4. This latter is easily obtained from keto-acid 1 and (R)-(-)-phenylglycinol.

Full text of DOI:10.1016/0040-4039(96)00819-2

Products guided by the article

Product name:(S)-6,7-Dimethoxy-2-((R)-1-phenyl-2-trimethylsilanyloxy-ethyl)-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonitrile

Cas No:180072-48-4

R&D Labs maybe for 180072-48-4

Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Xinjiang Zhongtai Chemical Co., Ltd.

Contact:+86-991-8788172

Address:NO.78 XISHAN RD.URUMQI，CHINA
Shanghai Kefu Chemical Co.,Ltd.

Contact:+86-21-34616196

Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
Du-Hope International Group

website:http://www.np-chem.com

Contact:0086-25-52346877

Address:199, Jian Ye Road, Nanjing, China
Quzhou Hopemax Chemical Technology Co.Ltd

Contact:86-570-3036007

Address:Room 801,Building 2,Wealth Center,No.51,Xujiang Road,Quzhou,China.

Relevant to this article

Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold

Doi:10.1021/jm200770f
(2011)
An Improved Protocol for the Synthesis and Purification of Yariv Reagents

Doi:10.1021/acs.joc.0c01812
(2020)
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain; Structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaliue, and cinnoline moieties

Doi:10.1021/jm0492958
(2005)
Doi:10.1246/bcsj.48.3409
(1975)
Doi:10.1021/ja01311a021
(1935)
The synthesis of tris(perfluoroalkyl)phosphines

Doi:10.1039/b507752d
(2005)

Article Doi