A new protecting group for aspartic acid that minimizes piperidine-catalyzed aspartimide formation in fmoc solid phase peptide synthesis

DOI: 10.1016/0040-4039(96)00807-6

Source and publish data:

Tetrahedron Letters p. 4243 - 4246 (1996)

Update date:2022-08-03

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Authors:

Karlstroem, Amelie

Unden, Anders

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Article abstract of DOI:10.1016/0040-4039(96)00807-6

The β-3-methylpent-3-yl ester of Fmoc aspartic acid, Fmoc-Asp(OMpe)-OH, is presented as a new protecting group for aspartic acid which provides good protection against base-catalyzed aspartimide formation in Fmoc solid phase peptide synthesis. Copyright

Full text of DOI:10.1016/0040-4039(96)00807-6

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