Bioorganic and Medicinal Chemistry Letters p. 1947 - 1950 (1996)
Update date:2022-09-26
Topics:
McKittrick, Brian A.
Ma, Ke
Dugar, Sundeep
Clader, John W.
Davis Jr., Harry
Czarniecki, Michael
McPhail, Andrew T.
The C-3 sidechain of azetidinones related to SCH 48461 was modified by introducing a hydroxyl group at the 1' position. This led to the discovery of the cis azetidinone 2c, which had improved CAI activity. Compound 2c was prepared using a selective reduction and silane mediated debromination to control the relative stereochemistry of the three centers.
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Doi:10.1016/0040-4039(96)01421-9
(1996)Doi:10.1134/S1070428010030188
(2010)Doi:10.1039/a805762a
(1998)Doi:10.1016/0040-4039(96)01754-6
(1996)Doi:10.1016/0040-4039(96)01645-0
(1996)Doi:10.1039/cc9960002355
(1996)