Bioorganic and Medicinal Chemistry Letters p. 2077 - 2080 (1996)
Update date:2022-08-05
Topics: Antibacterial activity Structure-Activity Relationship (SAR) Studies Regulatory Approval Safety and Toxicity
Kim, Myoung Goo
Jung, Jae Chul
Sung, Moo Je
Choi, Young Key
An, Sang Geun
Lee, Se-Jong
Yoon, Geal-Jung
Park, Myung Hwan
The synthesis and in vitro activity of cephalosporins with hydroxamic acid at the 7-position are described. Anti-pseudomonal activity of the compound 11a was shown to be comparable to that of ceftazidime. Especially, the compound 11a exhibited good activity against Gram-positive bacteria including Streptococcus pneumoniae and Staphylococcus aureus.
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Doi:10.1021/ja00315a008
(1984)Doi:10.1002/jhet.5570330453
(1996)Doi:10.1016/0040-4020(96)00685-0
(1996)Doi:10.1016/1381-1169(96)00168-9
(1996)Doi:10.1016/0960-894X(96)00349-6
(1996)Doi:10.1021/acs.orglett.6b00665
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