A novel, stereocontrolled approach to ring B alkylated estratetraenes

Article abstract of DOI:10.1016/0040-4039(96)01342-1

A four-step reaction protocol, culminating in an oxy-Cope rearrangement, has been developed to transform 2 into 7. 9α-Alkylated derivatives of equilin, e.g., 12, as well as C(7)-C(9) propano-bridged 19-norsteroids, like 17, demonstrate synthetic potential for 7 in estrogen receptor ligand synthesis.