Bioorganic and Medicinal Chemistry Letters p. 1715 - 1718 (1996)
Update date:2022-08-04
Topics:
Ye, Jianhua
Doerrler, William T.
Lehrman, Mark A.
Falck
Analogs of GPI membrane anchor precursors were prepared from chiral inositol 1 and evaluated as substrates in rodent and trypanosomal cell-free incubates. Di-octanoyl GlcNα-PI 5b was an efficient mannose acceptor whereas di-palmitoyl GlcNα-PI 5a was unexpectedly refractory. Di-octanoyl β-anomer 8 was mannosylated only under conditions that permitted acylation of the inositol residue.
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