A new method for aromatic difluoromethylation: Copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides

DOI: 10.1021/ol202289z

Source and publish data:

Organic Letters p. 5560 - 5563 (2011)

Update date:2022-08-02

Topics:

Authors:

Fujikawa, Kenichi

Fujioka, Yasutaka

Kobayashi, Akira

Amii, Hideki

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Article abstract of DOI:10.1021/ol202289z

A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.

Full text of DOI:10.1021/ol202289z

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