Preparation of new trifluoromethyl substituted Tri- and tetracyclic heterocycles with peganin skeleton from a methyl 3,3,3-trifluoropyruvate/2-aminobenzylamine adduct

Article abstract of DOI:10.1016/0040-4039(96)01517-1

Addition of 2-aminobenzylamino to methyl trifluoropyruvate afforded methyl 2-((2-aminobenzyl)amino)-3,3,3-trifluoro-2-hydroxypropionate, which reacted with various ketones to give new fluorinated tricyclic and tetracyclic heterocycles with the skeleton of