Synthesis of 5'-phosphonate linked thymidine deoxyoligonucleotides

DOI: 10.1016/0040-4039(96)01437-2

Source and publish data:

Tetrahedron Letters p. 6457 - 6460 (1996)

Update date:2022-08-05

Topics:

Authors:

Kofoed, Thomas

Caruthers, Marvin H.

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Article abstract of DOI:10.1016/0040-4039(96)01437-2

5'-Deoxy-5'-phosphonothymidine was synthesized and coupled with 3'-deoxy-3'-hydroxy-methylthymidine to yield a 3'-C-O-P-5' linked thymidine dinucleotide. This dimer as its 3'-phosphoramidite was used to synthesize deoxyoligonucleotides.

Full text of DOI:10.1016/0040-4039(96)01437-2

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