Synthesis and preliminary biochemical studies with 5'-deoxy-5'-methylidyne phosphonate linked thymidine oligonucleotides

DOI: 10.1016/0040-4039(96)01380-9

Source and publish data:

Tetrahedron Letters p. 6239 - 6242 (1996)

Update date:2022-08-04

Topics:

Authors:

Zhao, Zhengyun

Caruthers, Marvin H.

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Article abstract of DOI:10.1016/0040-4039(96)01380-9

Thymidine deoxyoligonucleotides having a 5'-deoxy-5'-methylidyne phosphonate internucleotide linkage were synthesized. Relative to natural DNA, these oligomers were nuclease resistant and formed duplexes with reduced stability.

Full text of DOI:10.1016/0040-4039(96)01380-9

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