Synthesis and preliminary biochemical studies with 5'-deoxy-5'-methylidyne phosphonate linked thymidine oligonucleotides

Article abstract of DOI:10.1016/0040-4039(96)01380-9

Thymidine deoxyoligonucleotides having a 5'-deoxy-5'-methylidyne phosphonate internucleotide linkage were synthesized. Relative to natural DNA, these oligomers were nuclease resistant and formed duplexes with reduced stability.