Synthesis of curacin A, an antimitotic cyclopropane-thiazoline from the marine cyanobacterium Lyngbya majuscula

DOI: 10.1016/0040-4039(96)01616-4

Source and publish data:

Tetrahedron Letters p. 7167 - 7170 (1996)

Update date:2022-07-29

Topics:

Authors:

Lai, Jing-Yu

Yu, Jurong

Mekonnen, Belew

Falck Falck

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Article abstract of DOI:10.1016/0040-4039(96)01616-4

Charette asymmetric cyclopropanation, chiral thiazoline synthesis by thioamide cyclization under modified Mitsunobu conditions, Ti(iPrO)₄/bi-naphthol catalyzed allylstannane addition, and an exceptionally mild two-carbon homologation via dehydrative alkylation with phenylsulfonylacetonitrile/Ph₃P/ADDP convened in an efficient, stereocontrolled route to the title bioactive heterocycle.

Full text of DOI:10.1016/0040-4039(96)01616-4

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