Synthesis of 3-[1H-imidazol-4-yl] propyl 4-[18F] fluorobenzyl ether ([18F] fluoroproxyfan): A potential radioligand for imaging histamine H3 receptors

DOI: 10.1002/1099-1344(200008)43:9<873::AID-JLCR371>3.0.CO;2-A

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 873 - 882 (2000)

Update date:2022-07-30

Topics:

Authors:

Iwata, Ren

Horvath, Geza

Pascali, Claudio

Bogni Bogni

Yanai, Kazuhiko

Kovacs, Zoltan

Ido, Tatsuo

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Article abstract of DOI:10.1002/1099-1344(200008)43:9<873::AID-JLCR371>3.0.CO;2-A

3-[1H-Imidazol-4-yl]propyl 4-fluorobenzyl ether (fluoroproxyfan), a potential histamine H₃ receptor ligand, was labeled with ¹⁸F for clinical PET studies. The synthesis involved the O-alkylation of 3-(1 -triphenylmethyl-1H-imidazol-4

Full text of DOI:10.1002/1099-1344(200008)43:9<873::AID-JLCR371>3.0.CO;2-A

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