European Journal of Medicinal Chemistry p. 2307 - 2312 (2009)
Update date:2022-07-29
Topics:
Jesudason, E. Philip
Sridhar
Malar, E.J. Padma
Shanmugapandiyan
Inayathullah, Mohammed
Arul
Selvaraj
Jayakumar
A novel series of N-Mannich bases of benzimidazole derivatives were synthesized and characterized by 1H NMR, IR spectral studies and elemental analysis. The compounds were screened for analgesic and anti-inflammatory activity. 1-((Diethylamino)-methyl)-2-styryl benzimidazole 4 at 40 mg/kg was found to be equipotent to paracetamol. 1-((Piperidin-1-yl) methyl)-2-styryl-benzimidazole 6 at 40 mg/kg was found to be more potent than Diclofenac. Corneal permeability and quantum chemical calculations were performed to correlate the hydrogen bonding ability with permeability and activity. The energies of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) were correlated with pharmacological activity. The semi-empirical PM3 calculations (quantum chemical calculations) revealed that ELUMO and energy gap ΔE were capable of accounting for the high in vitro bovine corneal permeability and activity of the compounds.
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