Synthesis of water soluble prodrug of DMP323

DOI: 10.1016/0960-894X(96)00391-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2259 - 2262 (1996)

Update date:2022-08-05

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Authors:

Jadhav, Prabhakar K.

Woerner, Francis J.

Aungst, Bruce J.

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Article abstract of DOI:10.1016/0960-894X(96)00391-5

A water soluble bisphosphate prodrug of DMP323 was synthesized from DMP323. Pharmacokinetic studies of the prodrug indicate that it is orally absorbed as the parent drug, after hydrolysis of the phosphate ester in the gastrointestinal tract.

Full text of DOI:10.1016/0960-894X(96)00391-5

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