Hydrophobic effects in duplexes with modified oligonucleotide backbones and RNA

DOI: 10.1016/0960-894X(96)00434-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2363 - 2366 (1996)

Update date:2022-08-05

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Authors:

Waldner, Adrian

De Mesmaeker, Alain

Wendeborn, Sebastian

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Article abstract of DOI:10.1016/0960-894X(96)00434-9

The incorporation of hydrophobic substituents on the amide functionality of modified oligonucleotides drastically influences the thermal stability of the corresponding duplexes with the RNA complement.

Full text of DOI:10.1016/0960-894X(96)00434-9

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