Helvetica Chimica Acta p. 1930 - 1938 (1996)
Update date:2022-08-03
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A new access to 2'-O-(2-methoxyethyl)ribonucleosides, building blocks for second-generation antisense oligonucleotides, is presented. The influence of various reaction parameters on the coupling reaction of 2-O-(2-methoxyethyl)-D-ribose derivatives with heteroaromatic bases as the key step was investigated, and reaction conditions were optimized with regard to formation of the desired β-D-anomers. With Sn2+ salts as promotors in polar solvents, these β-D-anomers were formed with a high degree of stereoselectivity.
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Doi:10.1246/bcsj.69.2977
(1996)Doi:10.1021/jm960414w
(1996)Doi:10.1016/S0957-4166(97)00435-7
(1997)Doi:10.1055/s-1995-3872
(1995)Doi:10.1021/om9606202
(1997)Doi:10.1007/s10600-015-1321-9
(2015)