Tetrahedron p. 13655 - 13670 (1996)
Update date:2022-08-03
Topics:
Hossain, Nafizal
Rozenski, Jef
De Clercq, Erik
Herdewijn, Piet
Starting from protected hexenetriol, acyclic analogues of the 1,5-anhydrohexitol nucleosides were synthesized. The reaction sequence involved a stereoselective Sharpless dihydroxylation and a Mitsunobu-type alkylation of the nucleoside bases. The compounds did not show antiviral activity.
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