Synthesis and antiviral activity of acyclic analogues of 1,5-anhydrohexitol nucleosides using Mitsunobu reaction

DOI: 10.1016/0040-4020(96)00818-6

Source and publish data:

Tetrahedron p. 13655 - 13670 (1996)

Update date:2022-08-03

Topics:

Authors:

Hossain, Nafizal

Rozenski, Jef

De Clercq, Erik

Herdewijn, Piet

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Article abstract of DOI:10.1016/0040-4020(96)00818-6

Starting from protected hexenetriol, acyclic analogues of the 1,5-anhydrohexitol nucleosides were synthesized. The reaction sequence involved a stereoselective Sharpless dihydroxylation and a Mitsunobu-type alkylation of the nucleoside bases. The compounds did not show antiviral activity.

Full text of DOI:10.1016/0040-4020(96)00818-6

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