Bioorganic and Medicinal Chemistry p. 135 - 143 (2000)
Update date:2022-09-26
Topics:
McCort, Isabelle
Fort, Sebastien
Dureault, Annie
Depezay, Jean-Claude
Selectively functionalized 2,5-imino-D-glucitol and 1,5-imino-D-mannitol derivatives were synthesized and tested as precursors of hydrolytically resistant pseudo-disaccharides. Among them N-acetyl-6-amino-6-deoxy-2,5- imino-D-glucitol (11) and N-acetyl-6-amino-6-deoxy-1,5-imino-D-mannitol (12) were found potent and specific inhibitors against β-D-glucosidase and α-L- fucosidase, respectively. (C) 2000 Elsevier Science Ltd.
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