Facile synthesis of 1-adamantyl esters of L-α-amino acids, a new class of carboxy protected derivatives

Article abstract of DOI:10.1055/s-1996-4396

1-Adamantyl esters of several N-unprotected L-α-amino acids were directly prepared in good optical purity and yield by reaction of the corresponding amino acid 4-toluenesulfonate salts with 1-adamantanol (AdOH) and dimethyl sulfite in boiling toluene. The