A diastereoselective tandem metalloenamine alkylation/aza-annulation of β-tetralones expedites the synthesis of benzoquinolinones

DOI: 10.1016/0040-4039(96)00724-1

Source and publish data:

Tetrahedron Letters p. 4121 - 4124 (1996)

Update date:2022-08-04

Topics:

Authors:

Audia, James E.

Droste, James J.

Dunigan, James M.

Bowers, John

Heath, Perry C.

Holme, Dale W.

Eifert, Jill H.

Kay, Harry A.

Miller, Richard D.

Olivares, Jorge M.

Rainey, Thomas F.

Weigel, Leland O.

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Article abstract of DOI:10.1016/0040-4039(96)00724-1

In one operation, metalloenamines derived from R-phenylethylamine (PEA) and a β-tetralone were treated with an electrophile followed by acrylic anhydride. The unpurified lactams were reduced to give 10b-angular benzoquinolinones (BQs).

Full text of DOI:10.1016/0040-4039(96)00724-1

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