The first practical asymmetric synthesis of R and S-warfarin

DOI: 10.1016/0040-4039(96)01796-0

Source and publish data:

Tetrahedron Letters p. 8321 - 8324 (1996)

Update date:2022-08-02

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Authors:

Robinson, Andrea

Li, Hui-Yin

Feaster, John

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Article abstract of DOI:10.1016/0040-4039(96)01796-0

A highly efficient synthesis of both enantiomers of warfarin Ia and Ib has been developed by using a novel two step 'chiral switch' strategy and a DuPHOS-Rh(I) catalyzed asymmetric hydrogenation.

Full text of DOI:10.1016/0040-4039(96)01796-0

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