Bioorganic and Medicinal Chemistry Letters p. 2859 - 2864 (1996)
Update date:2022-08-02
Topics:
Yu, Kuo-Long
Chen, Simon
Ostrowski, Jacek
Tramposch, Kenneth M.
Reczek, Peter R.
Mansuri, Muzammil M.
Starrett Jr., John E.
A series of truncated naphthoic acid retinoids have been prepared using the Heck reaction. These retinoids were evaluated in the RAR transactivation assay in vitro and in the utriculi reduction assay in vivo. It has been found that the naphthalene ring of the retinoids is crucial for their retinoid activity and receptor selectivity.
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