Enantioselective syntheses of (+)- and (-)-phaseolinic acid

Article abstract of DOI:10.1016/0040-4039(96)01941-7

(+)- and (-)-Phaseolinic acid (1) have been prepared in an enantioselective fashion from acetylenic acid 26 (or ent-26) by a three step sequence involving lactonization, epimerization at C₃, and oxidative cleavage. 26 was obtained as a single enantiomer using a Nicholas-Schreiber reaction.