Synthesis of a hybrid analog of the esperamicin and dynemicin cores

Article abstract of DOI:10.1016/S0040-4039(96)02010-2

An enediyne analog (2, R=H) that is a hybrid of the core structures of esperamicin and dynemicin was prepared. The key step in its synthesis was a Reissert-type reaction that involved intramolecular addition of the anion of a Z-1,3-diyn-2-ene to an N-acyl