Tetrahedron Letters p. 8233 - 8236 (1998)
Update date:2022-08-04
Topics:
Coppola, Gary M.
Isatoic anhydride (1) can be attached to Merrifield resin by alkylation on its nitrogen. A maximum loading of 3.2 mmol of anhydride/g of 5 was achieved. This resin, due to the highly reactive anhydride moiety, completely removes primary and secondary aliphatic amines from reactions where they are used in excess.
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