A novel synthetic approach to the preparation of various α,α-difluoroesters

Article abstract of DOI:10.1016/S0040-4039(96)02043-6

Treatment of readily available α-fluoro-β-hydroxy-α-phenylthioesters 4 with DAST afforded α,α-difluoro-β-phenylthioesters 6 which are of interest to synthesize gem-difluorinated derivatives.