Chemical and Pharmaceutical Bulletin p. 2280 - 2286 (1996)
Update date:2022-07-30
Topics:
Watanabe, Hiroyoshi
Hatakeyama, Susumi
Tazumi, Kazuki
Takano, Seiichi
Masuda, Sonoko
Okano, Toshio
Kobayashi, Tadashi
Kubodera, Noboru
As putative metabolites of 1α,25-dihydroxy-22-oxavitamin D3 (OCT), 24-hydroxylated OCT in 24(R) and 24(5) forms, 24-ketoOCT, 26-hydroxylated OCT in 25(S) and 25(R) forms, pentanorOCT and pentanor-ketoOCT were synthesized from the steroidal 20(S)-alcohol. Their antiproliferation activities towards human promyelocytic leukemia cells (HL-60 cells) are also reported. Oxidized derivatives at the C-24 position, 24-ketoOCT, 24(R)-hydroxylated OCT and 24(S)-hydroxylated OCT, showed activities comparable to or slightly weaker than that of OCT, while 26-hydroxylated OCT was less active than OCT. Truncated OCT, pentanor OCT and pentanor-ketoOCT, were inactive at 10-7-10-10M.
View MoreShanghai Bojing Chemical Co., Ltd.
Contact:021-37122233
Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
Laizhou City Laiyu Chemical CO.,Ltd
Contact:+86-535-2719337/2719339
Address:Chenggang road zhuyou laizhou City Shangdong China
Contact:+86-371-67759225
Address:No.32, Jinsuo Road, High-tech Zone
Shijiazhuang Sdyano Fine Chemical Co., Ltd
Contact:+86-311-89830448
Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Lanzhou huibang biological chemical technology Co., LTD
Contact:0931-7843964
Address:NO.2011,Yannan Road,Chengguan,
Doi:10.1135/cccc19961525
(1996)Doi:10.1021/jo970383s
(1997)Doi:10.1021/jm980400l
(1998)Doi:10.1039/P19960002889
(1996)Doi:10.1016/S0008-6215(96)00272-8
(1997)Doi:10.1021/ja963704a
(1997)
