Synthetic studies of vitamin D analogs. XXII. Synthesis and antiproliferation activity of putative metabolites of 1α,25-dihydroxy-22-oxavitamin D3

Article abstract of DOI:10.1248/cpb.44.2280

As putative metabolites of 1α,25-dihydroxy-22-oxavitamin D₃ (OCT), 24-hydroxylated OCT in 24(R) and 24(5) forms, 24-ketoOCT, 26-hydroxylated OCT in 25(S) and 25(R) forms, pentanorOCT and pentanor-ketoOCT were synthesized from the steroidal 20(S)-alcohol. Their antiproliferation activities towards human promyelocytic leukemia cells (HL-60 cells) are also reported. Oxidized derivatives at the C-24 position, 24-ketoOCT, 24(R)-hydroxylated OCT and 24(S)-hydroxylated OCT, showed activities comparable to or slightly weaker than that of OCT, while 26-hydroxylated OCT was less active than OCT. Truncated OCT, pentanor OCT and pentanor-ketoOCT, were inactive at 10^-7-10^-10M.

Full text of DOI:10.1248/cpb.44.2280

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