Tetrahedron Asymmetry p. 191 - 194 (1997)
Update date:2022-07-30
Topics:
Nagasaka, Tatsuo
Sato, Hiroto
Saeki, Shin-Ichiro
Racemic 1-azaspiro[4.4]nonane-2,6-dione 1 was easily synthesized from cyclopentanone in five steps and resolved via chiral acetals into enantiomers. Cephlotaxine (-)-3 and its enantiomer (+)-3 were obtained from (-)-1 and (+)-1, respectively, according to the literature.
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